+16.2
votes received
As far as effect goes I would have to say the biggest difference has to be emotions. While both of the substances open up "cognitive" connections, lsd seems to reach your deeper psychology. No matter how open a person is to their emotions there are always feelings that get repressed, its just how the brain works. It's like there’s always something there and LSD is going to bring it to the surface. This is why psychologists have done so much work with the substance.
+16.2